Suggested Use: 2 capsules, 1-2 times daily, with or between meals
RENUAL -
Mitochondrial renewal featuring Mitopure™ Urolithin A to power muscle function, increase cellular energy and promote healthy aging‡
Urolithin A is the main metabolite of ellagitannin-rich foods, such as pomegranates, black raspberries,
raspberries, strawberries, walnuts and almonds. These polyphenol components are not absorbed intact
into the bloodstream, but are hydrolyzed to ellagic acid in the gut, which is then metabolized by the gut
microflora to form urolithin A and B. Research indicates that the ability to synthesize urolithins declines
with age and depends on the gut microflora, and there is a small percentage of the population that is
unable to perform this conversion at all. Research indicates that urolithin A enhances autophagy, the
natural process of cellular renewal in which the body degrades and recycles cellular components, as well
as mitophagy, the clearance and recycling of older and dysfunctional mitochondria. Mitochondria are
the “powerhouses of the cell” and their function is fundamental to healthy aging. Efficient rejuvenation
of mitochondria supports energy production and the overall health of cells. A randomized, double-blind,
placebo-controlled trial involving healthy sedentary elderly subjects indicated that supplementation
with urolithin A promoted mitochondrial gene expression in the muscle and fatty acid oxidation efficacy,
showing support for mitochondrial biogenesis and function. Four weeks of urolithin A supplementation
resulted in improved mitochondrial function comparable to a 10-week aerobic exercise regimen, as
measured by decreases in plasma acylcarnitine. In animal research, urolithin A enhanced mitophagy to
promote mitochondrial biogenesis and function during aging. It also improved endurance and exercise
capacity in both young and age-related models of muscle decline. Supporting autophagy reduces
oxidative stress and promotes healthy cytokine balance within the cells to support healthy aging.
Preliminary research suggests a broad spectrum of support, including energy production, neuronal
health and neurogenesis, gut barrier function, and healthy joint collagen. Urolithin A also may offer
support for glucose and fat metabolism. When mice were fed a high-fat diet for 12 weeks,
supplementation with urolithin A promoted healthy insulin function and lipid metabolism, and
decreased adipocyte size. These results are believed to be the result of increased expression of genes
targeting fatty acid beta-oxidation, adipose tissue lipolysis and insulin receptor function (Sirt1), and
oxidation defenses (SOD1 and SOD2). Sirt1 is also a target of resveratrol, thereby offering support for
longevity, metabolic health, and mitochondrial function. CoQ10 is a key nutrient used in the energy
production pathway.
Kaneka Q10® is a U.S. registered trademark of Kaneka Corporation. Mitopure™ (proprietary Urolithin A) and the Mitopure™ logo are trademarks of Amazentis SA.
Supplement Facts:Suggested Use: 2 capsules, 1-2 times daily, with or between meals
Ingredients | AMT | %DV |
Mitopure™ Urolithin A | 125 mg | - |
Trans-Resveratrol (from Japanese knotweed (Polygonum cuspidatum) extract (root)) | 75 mg | - |
Coenzyme Q10 | 30 mg | - |
Other Ingredients: vegetable glycerin, vegetarian capsule (cellulose, water)
(-) There is no %DV or the manufactuer has not provided this data.
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